Human insulin is used in the treatment of diabetes mellitus (Type 1 & Type 2).
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Avoid consumption of alcohol while taking this medicine as it could aggravate your existing disease condition.
Ansulin N 100IU Vial can be used during pregnancy if prescribed by the physician. Therefore, consult your doctor before administration.
Ansulin N 100IU Vial is considered safe for use during breastfeeding. However, consult your doctor before administration.
Do not drive or operate any heavy tools or machines if your ability is affected by Ansulin N 100IU Vial.
Ansulin N 100IU Vial should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
Ansulin N 100IU Vial should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
Human insulin is a short-acting insulin, which starts working within 30 minutes after injection. It works similar to the insulin produced by the body. Insulin facilitates the reuptake of sugar in muscle and fat cells and also suppresses the production of sugar in the liver.
Allergic reactions. Injection site reaction, lipodystrophy, pruritus, rash, lipoatrophy, hypokalaemia, blurred vision. Hypoglycaemia, insulin resistance
Insulin lowers blood glucose levels. It regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal. The various insulin formulations are classified according to their durations of action after SC Inj. They are divided into short-, intermediate-, or long-acting insulin. Soluble insulin (also known as 'neutral insulin' or 'regular insulin') is a short-acting preparation. To extend the duration of action of insulin, preparations are formulated as suspensions in 2 methods. The 1st method involves complexing insulin with a protein so that it is slowly released, e.g. protamine zinc insulin (contains an excess of protamine) and isophane insulin (or NPH insulin which contains equal amounts of protamine and insulin). An alternative method is particle size modification e.g. insulin zinc suspensions. While all the formulations can be admin by SC inj, most by IM inj, only soluble insulin can be admin by IV. Compared to SC inj, IM admin usually has a faster onset of action, with a shorter duration of action.
Adult Dose
Subcutaneous Type 1 Diabetes Mellitus Suggested guidelines for beginning dose Usual daily maintenance range is 0.5-1 unit/kg/day SC in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.8-1.2 units/kg/day Type 2 Diabetes Mellitus Adult: Usual insulin requirement: 0.3-0.6 IU/kg/day; may be given in 1-2 divided doses. The dose should be individualized, to be adjusted according to the patient's needs. Suggested guidelines for beginning dose: 0.2 unit/kg/day May be used alone or in combination with a fast-acting insulin. Change insulin doses in small increments: Type 1 diabetes (2 unit change); type 2 diabetes (2-4 unit change). Look for consistent pattern in blood sugars for >3 days When combined with regular insulin: Morning Give two-thirds of daily insulin SC Ratio of regular insulin to NPH insulin 1:2 Evening Give one-third of daily insulin SC Ratio of regular insulin to NPH insulin 1:1 Dosing Considerations Dosage of human insulin, must be based on the results of blood and urine glucose tests and must be carefully individualized to optimal effect Dose adjustments should be based on regular blood glucose testing Adjust to achieve appropriate glucose control Hepatic impairment: Dosage reduction may be needed.
Child Dose
Type 1 Diabetes Mellitus <12 years: Safety and efficacy not established >12 years: Suggested dose is 0.5-1 unit/kg/day SC; use adult dosing; usual daily maintenance range in adolescents is <1.2 units/kg/day during growth spurts
Renal Dose
Renal impairment: Dose adjustments may be needed.
Administration
Administer within 15 minutes before a meal or immediately after a meal. Administer subcutaneously in the upper arm, thigh, or abdominal wall. A subcutaneous injection into the abdominal wall results in a faster absorption than from other injection sites. NPH Insulin suspensions are never to be administered intravenously.
Possible absence of hypoglycaemic warning symptoms with beta-blockers. Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotic (e.g. olanzapine and clozapine). Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics. Decreased insulin resistance with octreotide and lanreotide. Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.
Hypoglycaemia. Hypersensitivity to any of the components.
There are no restrictions on using insulin during pregnancy, as it does not pass the placental barrier.
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